Cage Environment Regulates Gut Microbiota Independent of Toll-Like Receptors.

ABSTRACT: The gut microbiome orchestrates epithelial homeostasis and both local and remote immunological responses. Critical to these regulatory interactions are innate immune receptors termed Toll-like receptors (TLRs). Studies to date have implicated innate immunity and Toll-like receptors in shaping key features of the gut microbiome. However, a variety of biological and environmental variables are also implicated in determining gut microbiota composition. In this report, we hypothesized that cohousing and environment dominated the regulation of the gut microbiota in animal models independent of innate immunity. To determine the importance of these variables, innate immunity, or environment in shaping gut microbiota, we used a randomized cohousing strategy and transgenic TLR-deficient mice. We ha

SUBMITTER: Lipinski JH 

PROVIDER: S-EPMC8370678 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature