Dynamically linking influenza virus infection kinetics, lung injury, inflammation, and disease severity.

ABSTRACT: Influenza viruses cause a significant amount of morbidity and mortality. Understanding host immune control efficacy and how different factors influence lung injury and disease severity are critical. We established and validated dynamical connections between viral loads, infected cells, CD8⁺ T cells, lung injury, inflammation, and disease severity using an integrative mathematical model-experiment exchange. Our results showed that the dynamics of inflammation and virus-inflicted lung injury are distinct and nonlinearly related to disease severity, and that these two pathologic measurements can be independently predicted using the model-derived infected cell dynamics. Our findings further indicated that the relative CD8⁺ T cell dynamics paralleled the percent of the lun

SUBMITTER: Myers MA 

PROVIDER: S-EPMC8370774 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature