Cardiorespiratory performance capacity and airway microbiome in patients following primary repair of esophageal atresia.

ABSTRACT:

Background

Patients following repair of an esophageal atresia (EA) or tracheoesophageal fistula (TEF) carry an increased risk of long-term cardiopulmonary malaise. The role of the airway microbiome in EA/TEF patients remains unclear.

Methods

All EA/TEF patients treated between 1980 and 2010 were invited to a prospective clinical examination, spirometry, and spiroergometry. The airway microbiome was determined from deep induced sputum by 16 S rRNA gene sequencing. The results were compared to a healthy age- and sex-matched control group.

Results

Nineteen EA/TEF patients with a mean age of 24.7 ± 7 years and 19 age- and sex-matched controls were included. EA/TEF patients showed a significantly lower muscle mass, lower maximum vital capacity (VC_max), and highe

SUBMITTER: Arneitz C 

PROVIDER: S-EPMC8370877 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature