Global metabolome profiling of exhaled breath condensates in male smokers with asthma COPD overlap and prediction of the disease.

ABSTRACT: Asthma-chronic obstructive pulmonary disease (COPD) overlap, termed as ACO, is a complex heterogeneous disease characterised by persistent airflow limitation, which manifests features of both asthma and COPD. These patients have a worse prognosis, in terms of more frequent and severe exacerbations, more frequent symptoms, worse quality of life, increased comorbidities and a faster lung function decline. In absence of clear diagnostic or therapeutic guidelines, ACO presents as a challenge to clinicians. The present study aims to investigate whether ACO patients have a distinct exhaled breath condensate (EBC) metabolic profile in comparison to asthma and COPD. A total of 132 age and BMI matched male smokers were recruited in the exploratory phase which consisted of (i) controls = 33 (ii) ast

SUBMITTER: Ghosh N 

PROVIDER: S-EPMC8370999 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature