Frequency-preference response in covalent modification cycles under substrate sequestration conditions.

ABSTRACT: Covalent modification cycles (CMCs) are basic units of signaling systems and their properties are well understood. However, their behavior has been mostly characterized in situations where the substrate is in excess over the modifying enzymes. Experimental data on protein abundance suggest that the enzymes and their target proteins are present in comparable concentrations, leading to substrate sequestration by the enzymes. In this enzyme-in-excess regime, CMCs have been shown to exhibit signal termination, the ability of the product to return to a stationary value lower than its peak in response to constant stimulation, while this stimulation is still active, with possible implications for the ability of systems to adapt to environmental inputs. We characterize the conditions leading to si

SUBMITTER: Szemere JR 

PROVIDER: S-EPMC8371027 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature