Molecular remission at T cell level in patients with rheumatoid arthritis.

ABSTRACT: While numerous disease-modifying anti-rheumatic drugs (DMARDs) have brought about a dramatic paradigm shift in the management of rheumatoid arthritis (RA), unmet needs remain, such as the small proportion of patients who achieve drug-free status. The aim of this study was to explore key molecules for remission at the T cell level, which are known to be deeply involved in RA pathogenesis, and investigate the disease course of patients who achieved molecular remission (MR). We enrolled a total of 46 patients with RA and 10 healthy controls (HCs). We performed gene expression profiling and selected remission signature genes in CD4⁺ T cells and CD8⁺ T cells from patients with RA using machine learning methods. In addition, we investigated the benefits of achieving MR on d

SUBMITTER: Inamo J 

PROVIDER: S-EPMC8371080 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature