Metformin treatment for 8 days impacts multiple intestinal parameters in high-fat high-sucrose fed mice.

ABSTRACT: Although the mechanism of action of the antidiabetic drug metformin is still a matter of discussions, it is well accepted that the gut plays an important role. To gain more insights into the mechanisms occurring in the different regions of the intestine, adult male mice were fed a high-fat-high sucrose (HFS) diet for 8 days and treated with metformin by gavage (300 mg/day/kg body weight) during the HFS diet. Metformin counteracted HFS diet-induced overexpression of a network of genes involved in the transport of glucose and fatty acids in the different regions of the small intestine. It also induced beneficial modification of secondary bile acid profile in the caecum, with a reduction of deoxycholic acid and lithocholic acid levels and increased abundance of ursodeoxycholic acid and taurou

SUBMITTER: Bravard A 

PROVIDER: S-EPMC8371110 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature