Evaluation of the Diagnostic Potential of a Plasma Exosomal miRNAs Panel for Gastric Cancer.

ABSTRACT:

Purpose

Gastric cancer (GC) is often difficult to diagnose early in the disease and remains one of the most frequently occurring malignancies. This investigation looks at the diagnostic potential of a specific plasma exosomal miRNAs panel for GC.

Methods

This study analyzed 216 individual peripheral blood samples. 2 GEO datasets were analyzed and two miRNAs were selected - plasma exosomal miR-195-5p and miR-211-5p. Quantitative reverse-transcriptase PCR (qRT-PCR) was used to assess relative expressions and receiver operating characteristic (ROC) curve analysis was used to determine the diagnostic efficiency of miR-195-5p and miR-211-5p panel. The Kaplan-Meier method was used to assess the prognostic value of plasma exosomal miR-195-5p and miR-211-5p.

Results

GC patien

SUBMITTER: Yang J 

PROVIDER: S-EPMC8371241 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature