Causal Effect of Blood Pressure on Bone Mineral Density and Fracture: A Mendelian Randomization Study.

ABSTRACT:

Background

Hypertension may have some association with osteoporosis. This Mendelian randomization (MR) study aimed to explore the causal effect of blood pressure (BP) on bone mineral density (BMD), fall, and fracture.

Methods

We used the genome-wide association study (GWAS) summary data among 330,956 European-descent individuals to identify 107 single-nucleotide polymorphisms (SNPs) as the instrumental variables of BP. MR analyses of these instruments were performed on 53,236 European individuals for the association with forearm BMD (FA-BMD), femoral neck BMD (FN-BMD), and lumbar spine BMD (LS-BMD); 451,179 European individuals for fall susceptibility; and up to 1.2 million individuals from European descent for fracture. Conventional inverse variance weighted (IVW) method wa

SUBMITTER: He B 

PROVIDER: S-EPMC8371435 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature