Seek and Find: Current Prospective Evidence for Prostate-specific Membrane Antigen Imaging to Detect Recurrent Prostate Cancer.

ABSTRACT:

Context

Men with biochemically relapsed prostate cancer face a clinical conundrum. Depending on the detected distribution of disease, treatment goals may range from cure with focal therapy to palliative with systemic therapy to expectant observation. Retrospective studies of prostate-specific membrane antigen (PSMA)-based imaging demonstrate higher disease detection rates than conventional imaging.

Objective

This review focuses on available prospective evidence for diagnostic use of PSMA-based imaging to accurately restage recurrent prostate cancer and explores the potential clinical impact, near future uses, and challenges for PSMA-based imaging in this setting.

Evidence acquisition

PubMed and EMBASE databases were searched for prospective studies with primary, secon

SUBMITTER: Keegan NM 

PROVIDER: S-EPMC8371443 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature