Development of a prognostic prediction model based on microRNA-1269a in esophageal cancer.

ABSTRACT:

Background

Esophageal cancer (ESCA) is a heterogeneous cancer with variable outcomes that are challenging to predict. MicroRNA (miR)-1269a is a newly discovered non-coding RNA that shows promising prognostic prediction in other cancers, but its clinical value in ESCA remains unclear.

Aim

To explore the relationship between miR-1269a and its clinical value and to develop a nomogram to succinctly display this relationship.

Methods

We analyzed the expression of miR-1269a in 125 ESCA tissue samples with complete clinical data and 52 normal tissue samples. We determined the prognostic value of miR-1269a for overall survival (OS) and cancer-specific survival (CSS) and evaluated the association between miR-1269a and clinical variables including tumor location, histologic gra

SUBMITTER: Yu Y 

PROVIDER: S-EPMC8371514 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature