B7 homologue 3 as a prognostic biomarker and potential therapeutic target in gastrointestinal tumors.

ABSTRACT: The most common digestive system (DS) cancers, including tumors of the gastrointestinal tract (GIT) such as colorectal cancer (CRC), gastric cancer (GC) and esophageal cancer (EC) as well as tumors of DS accessory organs such as pancreatic and liver cancer, are responsible for more than one-third of all cancer-related deaths worldwide, despite the progress that has been achieved in anticancer therapy. Due to these limitations in treatment strategies, oncological research has taken outstanding steps towards a better understanding of cancer cell biological complexity and heterogeneity. These studies led to new molecular target-driven therapeutic approaches. Different in vivo and in vitro studies have revealed significant expression of B7 homologue 3 (B7-H3) among the most commo

SUBMITTER: Rasic P 

PROVIDER: S-EPMC8371522 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature