Highly accurate protein structure prediction with AlphaFold.

ABSTRACT: Proteins are essential to life, and understanding their structure can facilitate a mechanistic understanding of their function. Through an enormous experimental effort^1-4, the structures of around 100,000 unique proteins have been determined⁵, but this represents a small fraction of the billions of known protein sequences^6,7. Structural coverage is bottlenecked by the months to years of painstaking effort required to determine a single protein structure. Accurate computational approaches are needed to address this gap and to enable large-scale structural bioinformatics. Predicting the three-dimensional structure that a protein will adopt based solely on its amino acid sequence-the structure prediction component of the 'protein folding problem'⁸-h

SUBMITTER: Jumper J 

PROVIDER: S-EPMC8371605 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature