Clinicopathologic and Molecular Characteristics of Gastrointestinal MiNENs.

ABSTRACT:

Background

A mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) is a recently defined entity that comprises a neuroendocrine tumor (NEN) component and a non-neuroendocrine tumor (nNEN) component. As MiNEN is a recently defined entity, its molecular nature is not well known. Here, we evaluated the clinicopathologic and molecular characteristics of gastrointestinal (GI) MiNENs.

Methods

We performed a genomic analysis of 31 samples from 12 GI MiNEN cases using next-generation sequencing. We examined the primary NEN and nNEN components, as well as the metastatic NENs and nNENs. The relationships between the clinical tumor features (component, location, and grade) and their molecular characteristics were examined.

Results

The 12 MiNENs included in the study were foun

SUBMITTER: Yeo MK 

PROVIDER: S-EPMC8371704 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature