A history of uraemic toxicity and of the European Uraemic Toxin Work Group (EUTox).

ABSTRACT: The uraemic syndrome is a complex clinical picture developing in the advanced stages of chronic kidney disease, resulting in a myriad of complications and a high early mortality. This picture is to a significant extent defined by retention of metabolites and peptides that with a preserved kidney function are excreted or degraded by the kidneys. In as far as those solutes have a negative biological/biochemical impact, they are called uraemic toxins. Here, we describe the historical evolution of the scientific knowledge about uraemic toxins and the role played in this process by the European Uraemic Toxin Work Group (EUTox) during the last two decades. The earliest knowledge about a uraemic toxin goes back to the early 17th century when the existence of what would later be named as urea was

SUBMITTER: Vanholder R 

PROVIDER: S-EPMC8371716 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature