Bone marrow mesenchymal stem cells derived from juvenile macaques reversed ovarian ageing in elderly macaques.

ABSTRACT:

Background

Female sex hormone secretion and reproductive ability decrease with ageing. Bone marrow mesenchymal stem cells (BMMSCs) have been postulated to play a key role in treating ovarian ageing.

Methods

We used macaque ovarian ageing models to observe the structural and functional changes after juvenile BMMSC treatment. Moreover, RNA-seq was used to analyse the ovarian transcriptional expression profile and key pathways through which BMMSCs reverse ovarian ageing.

Results

In the elderly macaque models, the ovaries were atrophied, the regulation ability of sex hormones was reduced, the ovarian structure was destroyed, and only local atretic follicles were observed, in contrast with young rhesus monkeys. Intravenous infusion of BMMSCs in elderly macaques increased o

SUBMITTER: Tian C 

PROVIDER: S-EPMC8371769 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature