Combination of white matter hyperintensities and Aβ burden is related to cognitive composites domain scores in subjective cognitive decline: the FACEHBI cohort.

ABSTRACT:

Background

To explore whether the combination of white matter hyperintensities (WMHs) and amyloid-beta (Aβ) deposition is associated with worse cognitive performance on cognitive composites (CCs) domain scores in individuals with subjective cognitive decline (SCD).

Methods

Two hundred participants from the FACEHBI cohort underwent structural magnetic resonance imaging (MRI), ¹⁸F-florbetaben positron emission tomography (FBB-PET), and neuropsychological assessment. WMHs were addressed through the Fazekas scale, the Age-Related White Matter Changes (ARWMC) scale, and the FreeSurfer pipeline. Eight CCs domain scores were created using the principal component analysis (PCA). Age, sex, education, and apolipoprotein E (APOE) were used as adjusting variables.

Results<

SUBMITTER: Ortega G 

PROVIDER: S-EPMC8371791 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature