Direct differentiation of tonsillar biopsy-derived stem cells to the neuronal lineage.

ABSTRACT:

Background

Neurological disorders are considered one of the greatest burdens to global public health and a leading cause of death. Stem cell therapies hold great promise for the cure of neurological disorders, as stem cells can serve as cell replacement, while also secreting factors to enhance endogenous tissue regeneration. Adult human multipotent stem cells (MSCs) reside on blood vessels, and therefore can be found in many tissues throughout the body, including palatine tonsils. Several studies have reported the capacity of MSCs to differentiate into, among other cell types, the neuronal lineage. However, unlike the case with embryonic stem cells, it is unclear whether MSCs can develop into mature neurons.

Methods

Human tonsillar MSCs (T-MSCs) were isolated from a small, 0

SUBMITTER: Arad M 

PROVIDER: S-EPMC8371824 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature