Intestinal Regulatory T Cells as Specialized Tissue-Restricted Immune Cells in Intestinal Immune Homeostasis and Disease.

ABSTRACT: FOXP3⁺ regulatory T cells (Treg cells) are a specialized population of CD4⁺ T cells that restrict immune activation and are essential to prevent systemic autoimmunity. In the intestine, the major function of Treg cells is to regulate inflammation as shown by a wide array of mechanistic studies in mice. While Treg cells originating from the thymus can home to the intestine, the majority of Treg cells residing in the intestine are induced from FOXP3^neg conventional CD4⁺ T cells to elicit tolerogenic responses to microbiota and food antigens. This process largely takes place in the gut draining lymph nodes via interaction with antigen-presenting cells that convert circulating naïve T cells into Treg cells. Notably, dysregulation of Treg cells

SUBMITTER: Jacobse J 

PROVIDER: S-EPMC8371910 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature