Liver disease symptoms are associated with higher risk of adverse clinical outcomes: A longitudinal study of North American adults with chronic Hepatitis B.

ABSTRACT:

Background

Symptoms of chronic hepatitis B (CHB) are not well characterized.

Aims

To evaluate CHB symptoms and associations with disease activity and clinical outcomes.

Methods

Longitudinal data from 1,576 participants in the Hepatitis B Research Network Cohort Study who completed symptom assessments were analyzed. A composite symptom score was calculated using a Symptom Checklist (0=none to 40=extreme). Multivariable mixed models assessed variables associated with symptom change over time. Latent class symptom trajectories were evaluated. The cumulative probability of long-term clinical outcomes (new onset cirrhosis, hepatic decompensation, hepatocellular carcinoma, liver transplantation, death) was examined by baseline symptom groups.

Results

Participants med

SUBMITTER: Evon DM 

PROVIDER: S-EPMC8372034 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature