The medicinal chemistry of mitochondrial dysfunction: a critical overview of efforts to modulate mitochondrial health.

ABSTRACT: Mitochondria are subcellular organelles that perform a variety of critical biological functions, including ATP production and acting as hubs of immune and apoptotic signalling. Mitochondrial dysfunction has been extensively linked to the pathology of multiple neurodegenerative disorders, resulting in significant investment from the drug discovery community. Despite extensive efforts, there remains no disease modifying therapies for neurodegenerative disorders. This manuscript aims to review the compounds historically used to modulate the mitochondrial network through the lens of modern medicinal chemistry, and to offer a perspective on the evidence that relevant exposure was achieved in a representative model and that exposure was likely to result in target binding and engagement of pharma

SUBMITTER: Lee MTW 

PROVIDER: S-EPMC8372206 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature