Genome-wide association study identifies <i>RNF123</i> locus as associated with chronic widespread musculoskeletal pain.

ABSTRACT:

Background and objectives

Chronic widespread musculoskeletal pain (CWP) is a symptom of fibromyalgia and a complex trait with poorly understood pathogenesis. CWP is heritable (48%-54%), but its genetic architecture is unknown and candidate gene studies have produced inconsistent results. We conducted a genome-wide association study to get insight into the genetic background of CWP.

Methods

Northern Europeans from UK Biobank comprising 6914 cases reporting pain all over the body lasting >3 months and 242 929 controls were studied. Replication of three independent genome-wide significant single nucleotide polymorphisms was attempted in six independent European cohorts (n=43 080; cases=14 177). Genetic correlations with risk factors, tissue specificity and colocalisation were e

SUBMITTER: Rahman MS 

PROVIDER: S-EPMC8372387 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature