Ontology highlight
ABSTRACT:
SUBMITTER: Melo CM
PROVIDER: S-EPMC8372403 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Melo Carina Mucciolo CM Wang Huawei H Fujimura Ken K Strnadel Jan J Meneghetti Maria Cecília Zorél MCZ Nader Helena Bonciani HB Klemke Richard L RL Pinhal Maria Aparecida Silva MAS
Frontiers in oncology 20210804
Angiogenesis is the formation of new vessels from pre-existing vasculature. The heparan sulfate chains from endothelial cell proteoglycans interact with the major angiogenic factors, regulating blood vessels´ formation. Since the FDA´s first approval, anti-angiogenic therapy has shown tumor progression inhibition and increased patient survival. Previous work in our group has selected an HS-binding peptide using a phage display system. Therefore, we investigated the effect of the selected peptide ...[more]