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The Heparan Sulfate Binding Peptide in Tumor Progression of Triple-Negative Breast Cancer.


ABSTRACT: Angiogenesis is the formation of new vessels from pre-existing vasculature. The heparan sulfate chains from endothelial cell proteoglycans interact with the major angiogenic factors, regulating blood vessels´ formation. Since the FDA´s first approval, anti-angiogenic therapy has shown tumor progression inhibition and increased patient survival. Previous work in our group has selected an HS-binding peptide using a phage display system. Therefore, we investigated the effect of the selected peptide in angiogenesis and tumor progression. The HS-binding peptide showed a higher affinity for heparin N-sulfated. The HS-binding peptide was able to inhibit the proliferation of human endothelial umbilical cord cells (HUVEC) by modulation of FGF-2. It was verified a significant decrease in the tube formation of human endothelial cells and capillary formation of mice aorta treated with HS-binding peptide. HS-binding peptide also inhibited the formation of sub-intestinal blood vessels in zebrafish embryos. Additionally, in zebrafish embryos, the tumor size decreased after treatment with HS-binding peptide.

SUBMITTER: Melo CM 

PROVIDER: S-EPMC8372403 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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The Heparan Sulfate Binding Peptide in Tumor Progression of Triple-Negative Breast Cancer.

Melo Carina Mucciolo CM   Wang Huawei H   Fujimura Ken K   Strnadel Jan J   Meneghetti Maria Cecília Zorél MCZ   Nader Helena Bonciani HB   Klemke Richard L RL   Pinhal Maria Aparecida Silva MAS  

Frontiers in oncology 20210804


Angiogenesis is the formation of new vessels from pre-existing vasculature. The heparan sulfate chains from endothelial cell proteoglycans interact with the major angiogenic factors, regulating blood vessels´ formation. Since the FDA´s first approval, anti-angiogenic therapy has shown tumor progression inhibition and increased patient survival. Previous work in our group has selected an HS-binding peptide using a phage display system. Therefore, we investigated the effect of the selected peptide  ...[more]

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