In silico Screening and Behavioral Validation of a Novel Peptide, LCGA-17, With Anxiolytic-Like Properties.

ABSTRACT: The aim of the study was to develop better anxiolytics and antidepressants. We focused on GABA _A receptors and the α2δ auxiliary subunit of V-gated Ca²⁺ channels as putative targets because they are established as mediators of efficacious anxiolytics, antidepressants, and anticonvulsants. We further focused on short peptides as candidate ligands because of their high safety and tolerability profiles. We employed a structural bioinformatics approach to develop novel tetrapeptides with predicted affinity to GABA _A receptors and α2δ. In silico docking studies of one of these peptides, LCGA-17, showed a high binding score for both GABA _A receptors and α2δ, combined with anxiolytic-like properties in a Danio rerio be

SUBMITTER: Malyshev AV 

PROVIDER: S-EPMC8372404 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature