Structural and Genomic Insights Into Pyrazinamide Resistance in <i>Mycobacterium tuberculosis</i> Underlie Differences Between Ancient and Modern Lineages.

ABSTRACT: Resistance to drugs used to treat tuberculosis disease (TB) continues to remain a public health burden, with missense point mutations in the underlying Mycobacterium tuberculosis bacteria described for nearly all anti-TB drugs. The post-genomics era along with advances in computational and structural biology provide opportunities to understand the interrelationships between the genetic basis and the structural consequences of M. tuberculosis mutations linked to drug resistance. Pyrazinamide (PZA) is a crucial first line antibiotic currently used in TB treatment regimens. The mutational promiscuity exhibited by the pncA gene (target for PZA) necessitates computational approaches to investigate the genetic and structural basis for PZA resistance development. We analysed

SUBMITTER: Tunstall T 

PROVIDER: S-EPMC8372558 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature