Time-dependent transformations of memory representations differ along the long axis of the hippocampus.

ABSTRACT: Research has shown that sleep is beneficial for the long-term retention of memories. According to theories of memory consolidation, memories are gradually reorganized, becoming supported by widespread, distributed cortical networks, particularly during postencoding periods of sleep. However, the effects of sleep on the organization of memories in the hippocampus itself remains less clear. In a 3-d study, participants encoded separate lists of word-image pairs differing in their opportunity for sleep-dependent consolidation. Pairs were initially studied either before or after an overnight sleep period, and were then restudied in a functional magnetic resonance imaging (fMRI) scan session. We used multivariate pattern similarity analyses to examine fine-grained effects of consolidation on me

SUBMITTER: Cowan ET 

PROVIDER: S-EPMC8372564 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature