Poor Endometrial Proliferation After Clomiphene is Associated With Altered Estrogen Action.

ABSTRACT:

Context

Suboptimal endometrial thickening is associated with lower pregnancy rates and occurs in some infertile women treated with clomiphene.

Objective

To examine cellular and molecular differences in the endometrium of women with suboptimal vs optimal endometrial thickening following clomiphene.

Methods

Translational prospective cohort study from 2018 to 2020 at a university-affiliated clinic. Reproductive age women with unexplained infertility treated with 100 mg of clomiphene on cycle days 3 to 7 who developed optimal (≥8mm; n = 6, controls) or suboptimal (<6mm; n = 7, subjects) endometrial thickness underwent preovulatory blood and endometrial sampling. The main outcome measures were endometrial tissue architecture, abundance and location of specific proteins, RN

SUBMITTER: Hawkins Bressler L 

PROVIDER: S-EPMC8372647 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature