Heritability of the Fibromyalgia Phenotype Varies by Age.

ABSTRACT:

Objective

Many studies suggest a strong familial component to fibromyalgia (FM). However, those studies have nearly all been confined to individuals with primary FM, i.e., FM without any other accompanying disorder. The current 2011 and 2016 criteria for diagnosing FM construct a score using a combination of the number of painful body sites and the severity of somatic symptoms (FM score). This study was undertaken to estimate the genetic heritability of the FM score across sex and age groups to identify subgroups of individuals with greater heritability, which may help in the design of future genetic studies.

Methods

We collected data on 26,749 individuals of European ancestry undergoing elective surgery at the University of Michigan (Michigan Genomics Initiative study). We

SUBMITTER: Dutta D 

PROVIDER: S-EPMC8372844 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature