Influenza Virus Infects and Depletes Activated Adaptive Immune Responders.

ABSTRACT: Influenza infections cause several million cases of severe respiratory illness, hospitalizations, and hundreds of thousands of deaths globally. Secondary infections are a leading cause of influenza's high morbidity and mortality, and significantly factored into the severity of the 1918, 1968, and 2009 pandemics. Furthermore, there is an increased incidence of other respiratory infections even in vaccinated individuals during influenza season. Putative mechanisms responsible for vaccine failures against influenza as well as other respiratory infections during influenza season are investigated. Peripheral blood mononuclear cells (PBMCs) are used from influenza vaccinated individuals to assess antigen-specific responses to influenza, measles, and varicella. The observations made in humans to

SUBMITTER: Bohannon CD 

PROVIDER: S-EPMC8373117 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature