Impact of YTHDF1 gene polymorphisms on Wilms tumor susceptibility: A five-center case-control study.

ABSTRACT:

Background

Wilms tumor is the most frequent renal malignancy in children. YTHDF1 is associated with the development of several kinds of cancers, yet whether common variants of the YTHDF1 gene influence Wilms tumor risk is unknown. We present, here, a hospital-based case-control study specifically designed to investigate the role of YTHDF1 genetic variants on Wilms tumor.

Methods

We successfully genotyped samples of 408 Wilms tumor cases and 1198 controls which were collected from five hospitals across China. The unconditional logistic regression was adopted to analyze the contributions of YTHDF1 gene single nucleotide polymorphisms (SNPs) to the risk of Wilms tumor. The odds ratio (OR) and 95% confidence interval (CI) were generated to evaluate the conferring risk of YTHDF1 

SUBMITTER: Liu Y 

PROVIDER: S-EPMC8373325 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature