The intrinsic chaperone network of Arabidopsis stem cells confers protection against proteotoxic stress.

ABSTRACT: The biological purpose of plant stem cells is to maintain themselves while providing new pools of differentiated cells that form organs and rejuvenate or replace damaged tissues. Protein homeostasis or proteostasis is required for cell function and viability. However, the link between proteostasis and plant stem cell identity remains unknown. In contrast to their differentiated counterparts, we find that root stem cells can prevent the accumulation of aggregated proteins even under proteotoxic stress conditions such as heat stress or proteasome inhibition. Notably, root stem cells exhibit enhanced expression of distinct chaperones that maintain proteome integrity. Particularly, intrinsic high levels of the T-complex protein-1 ring complex/chaperonin containing TCP1 (TRiC/CCT) complex deter

SUBMITTER: Llamas E 

PROVIDER: S-EPMC8373342 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature