Ontology highlight
ABSTRACT:
SUBMITTER: Kerns SJ
PROVIDER: S-EPMC8373379 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Kerns S Jordan SJ Belgur Chaitra C Petropolis Debora D Kanellias Marianne M Barrile Riccardo R Sam Johannes J Weinzierl Tina T Fauti Tanja T Freimoser-Grundschober Anne A Eckmann Jan J Hage Carina C Geiger Martina M Ng Patrick Ray PR Tien-Street William W Manatakis Dimitris V DV Micallef Virginie V Gerard Regine R Bscheider Michael M Breous-Nystrom Ekaterina E Schneider Anneliese A Giusti Anna Maria AM Bertinetti-Lapatki Cristina C Grant Heather Shannon HS Roth Adrian B AB Hamilton Geraldine A GA Singer Thomas T Karalis Katia K Moisan Annie A Bruenker Peter P Klein Christian C Bacac Marina M Gjorevski Nikolce N Cabon Lauriane L
eLife 20210811
Traditional drug safety assessment often fails to predict complications in humans, especially when the drug targets the immune system. Here, we show the unprecedented capability of two human Organs-on-Chips to evaluate the safety profile of T-cell bispecific antibodies (TCBs) targeting tumor antigens. Although promising for cancer immunotherapy, TCBs are associated with an on-target, off-tumor risk due to low levels of expression of tumor antigens in healthy tissues. We leveraged in vivo target ...[more]