Dynamics of Top-Down Control and Motor Networks in Parkinson's Disease.

ABSTRACT:

Background

Motor symptoms in Parkinson's disease (PD) patients might be related to high-level task-control deficits. We aimed at investigating the dynamics between sensorimotor network and top-down control networks (frontal-parietal, cingulo-opercular, and cerebellar) in PD and at determining the effects of levodopa on the dynamics of these networks.

Methods

We investigated dynamic functional connectivity (dFC), during resting state functional magnetic resonance imaging, between sensorimotor network and top-down control networks in 36 PD patients (OFF medication, PD-OFF) and 36 healthy volunteers. We further assessed the effect of medication on dFC in18 PD patients who were also scanned ON medication.

Results

The dFC analyses identified three discrete states: State I

SUBMITTER: Chen L 

PROVIDER: S-EPMC8373438 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature