Childhood vascular phenotypes have differing associations with prenatal and postnatal growth.

ABSTRACT:

Objective

In children aged 8--9 years, we examined the associations of linear and abdominal circumference growth during critical stages of prenatal and postnatal development with six vascular measurements commonly used as early markers of atherosclerosis and later cardiovascular disease (CVD) risk.

Methods

In 724 children from the UK Southampton Women's Survey mother--offspring cohort, offspring length/height and abdominal circumference measurements were collected at 10 ages between 11 weeks' gestation and age 8--9 years. Using residual growth modelling and linear regression, we examined the independent associations between growth and detailed vascular measures made at 8--9 years.

Results

Postnatal linear and abdominal circumference growth were associated with higher

SUBMITTER: Sletner L 

PROVIDER: S-EPMC8373454 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature