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The origins of SARS-CoV-2: A critical review.

ABSTRACT: Since the first reports of a novel severe acute respiratory syndrome (SARS)-like coronavirus in December 2019 in Wuhan, China, there has been intense interest in understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in the human population. Recent debate has coalesced around two competing ideas: a "laboratory escape" scenario and zoonotic emergence. Here, we critically review the current scientific evidence that may help clarify the origin of SARS-CoV-2.

SUBMITTER: Holmes EC

PROVIDER: S-EPMC8373617 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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The origins of SARS-CoV-2: A critical review.

Holmes Edward C EC Goldstein Stephen A SA Rasmussen Angela L AL Robertson David L DL Crits-Christoph Alexander A Wertheim Joel O JO Anthony Simon J SJ Barclay Wendy S WS Boni Maciej F MF Doherty Peter C PC Farrar Jeremy J Geoghegan Jemma L JL Jiang Xiaowei X Leibowitz Julian L JL Neil Stuart J D SJD Skern Tim T Weiss Susan R SR Worobey Michael M Andersen Kristian G KG Garry Robert F RF Rambaut Andrew A

Cell 20210819 19

Since the first reports of a novel severe acute respiratory syndrome (SARS)-like coronavirus in December 2019 in Wuhan, China, there has been intense interest in understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in the human population. Recent debate has coalesced around two competing ideas: a "laboratory escape" scenario and zoonotic emergence. Here, we critically review the current scientific evidence that may help clarify the origin of SARS-CoV-2. ...[more]

PMID: 34480864

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Tracing the origins of SARS-COV-2 in coronavirus phylogenies: a review.

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