Midazolam Premedication Immediately Before Surgery Is Not Associated With Early Postoperative Delirium.

ABSTRACT:

Background

Postoperative delirium is common among older surgical patients and may be associated with anesthetic management during the perioperative period. The aim of this study is to assess whether intravenous midazolam, a short-acting benzodiazepine used frequently as premedication, increased the incidence of postoperative delirium.

Methods

Analyses of existing data were conducted using a database created from 3 prospective studies in patients aged 65 years or older who underwent elective major noncardiac surgery. Postoperative delirium occurring on the first postoperative day was measured using the confusion assessment method. We assessed the association between the use or nonuse of premedication with midazolam and postoperative delirium using a χ2 test, using propensity

SUBMITTER: Wang ML 

PROVIDER: S-EPMC8373629 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature