Variation in propofol induction doses administered to surgical patients over age 65.

ABSTRACT:

Background/objectives

Advanced age is associated with increased susceptibility to acute adverse effects of propofol. The present study aimed to describe patterns of propofol dosing for induction of general anesthesia before endotracheal intubation in a nationwide sample of older adults presenting for surgery.

Design

Retrospective observational study using the Multicenter Perioperative Outcomes Group data set.

Setting

Thirty-six institutions across the United States.

Participants

A total of 350,766 patients aged over 65 years who received propofol for general anesthetic induction and endotracheal intubation between 2014 and 2018.

Intervention

None.

Measurements

Total induction bolus dose of propofol administered.

Results

The mean (SD) weight

SUBMITTER: Schonberger RB 

PROVIDER: S-EPMC8373684 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature