Genetics in sarcoidosis.

ABSTRACT:

Purpose of review

Epidemiological and clinical observations as well as familial clustering support the existence of a genetic predisposition to sarcoidosis. In this article, we review the most recent findings in genetics of sarcoidosis and discuss how the identification of risk alleles may help advancing our understanding of disease etiology and development.

Recent findings

Genetic studies of sarcoidosis phenotypes have identified novel and ancestry-specific associations. Gene-environment interaction studies highlighted the importance of integrating genetic information when assessing the relationship between sarcoidosis and environmental exposures. A case-control-family study revealed that the heritability of sarcoidosis is only 49%, suggesting the existence of additional im

SUBMITTER: Spagnolo P 

PROVIDER: S-EPMC8373710 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature