Reduced cortical GABA and glutamate in high schizotypy.

ABSTRACT:

Rationale

Abnormal functioning of the inhibitory gamma-aminobutyric acid (GABA) and excitatory (glutamate) systems is proposed to play a role in the development of schizophrenia spectrum disorder. Although results are mixed, previous 1H-magnetic resonance spectroscopy (MRS) studies in schizophrenia and clinical high-risk samples report these metabolites are altered in comparison to healthy controls. Currently, however, there are few studies of these metabolites in schizotypy samples, a personality dimension associated with the experience of schizophrenia and psychosis-like symptoms.

Objectives

We investigated if GABA and glutamate metabolite concentrations are altered in people with high schizotypy. We also explored the relationship between resilience to stress, GABA metabol

SUBMITTER: Kozhuharova P 

PROVIDER: S-EPMC8373725 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature