Cannabinoid signaling promotes the de-differentiation and proliferation of Muller glia-derived progenitor cells.

ABSTRACT: Endocannabinoids (eCB) are lipid-based neurotransmitters that are known to influence synaptic function in the visual system. eCBs are also known to suppress neuroinflammation in different pathological states. However, nothing is known about the roles of the eCB system during the transition of Müller glia (MG) into proliferating progenitor-like cells in the retina. Accordingly, we used the chick and mouse model to characterize expression patterns of eCB-related genes and applied pharmacological agents to investigate how the eCB system impacts glial reactivity and the capacity of MG to become Müller glia-derived progenitor cells (MGPCs). We queried single cell RNA-seq libraries to identify eCB-related genes and identify cells with dynamic patterns of expression in damaged retinas. MG and inn

SUBMITTER: Campbell WA 

PROVIDER: S-EPMC8373766 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature