Burden of Cardiomyopathic Genetic Variation in Lethal Pediatric Myocarditis.

ABSTRACT:

Background

Acute myocarditis (AM) is a well-known cause of sudden death and heart failure, often caused by prevalent viruses. We previously showed that some pediatric AM correlates with putatively damaging variants in genes related to cardiomyocyte structure and function. We sought to evaluate whether deleterious cardiomyopathic variants were enriched among fatal pediatric AM cases in New York City compared with ancestry-matched controls.

Methods

Twenty-four children (aged 3 weeks to 20 years) with death due to AM were identified through autopsy records; histologies were reviewed to confirm that all cases met Dallas criteria for AM and targeted panel sequencing of 57 cardiomyopathic genes was performed. Controls without cardiovascular disease were identified from a pediatric

SUBMITTER: Kontorovich AR 

PROVIDER: S-EPMC8373803 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature