Real-world treatment escalation from metformin monotherapy in youth-onset Type 2 diabetes mellitus: A retrospective cohort study.

ABSTRACT:

Background

Due to high rates of comorbidities and rapid progression, youth with Type 2 diabetes may benefit from early and aggressive treatment. However, until 2019, the only approved medications for this population were metformin and insulin.

Objective

To investigate patterns and predictors of treatment escalation within 5 years of metformin monotherapy initiation for youth with Type 2 diabetes in clinical practice.

Subjects

Commercially-insured patients with incident youth-onset (10-18 years) Type 2 diabetes initially treated with metformin only.

Methods

Retrospective cohort study using a patient-level medical claims database with data from 2000 to 2020. Frequency and order of treatment escalation to insulin and non-insulin antihyperglycemics were determined

SUBMITTER: Vajravelu ME 

PROVIDER: S-EPMC8373808 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature