NAD⁺ Redox Imbalance in the Heart Exacerbates Diabetic Cardiomyopathy.

ABSTRACT:

Background

Diabetes is a risk factor for heart failure and promotes cardiac dysfunction. Diabetic tissues are associated with nicotinamide adenine dinucleotide (NAD⁺) redox imbalance; however, the hypothesis that NAD⁺ redox imbalance causes diabetic cardiomyopathy has not been tested. This investigation used mouse models with altered NAD⁺ redox balance to test this hypothesis.

Methods

Diabetic stress was induced in mice by streptozotocin. Cardiac function was measured by echocardiography. Heart and plasma samples were collected for biochemical, histological, and molecular analyses. Two mouse models with altered NAD⁺ redox states (1, Ndufs4 [NADH:ubiquinone oxidoreductase subunit S4] knockout, cKO, and 2, NAMPT [nicotinamide phospho

SUBMITTER: Chiao YA 

PROVIDER: S-EPMC8373812 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature