Endoscopically Applied Biodegradable Stent in a Rabbit Model of Pediatric Tracheomalacia.

ABSTRACT:

Objectives

A polydioxanone (PDO) stent was developed to treat tracheomalacia in pediatric patients. However, its safety and efficacy need to be verified in animal studies before clinical trials in patients can be conducted. This study evaluated the safety and efficacy of a PDO stent in normal and tracheomalacia-model rabbits.

Methods

In total, 29 New Zealand white rabbits were used: 13 for evaluating the biocompatibility of the PDO stent in normal rabbits and 16 for the creation of a tracheomalacia model. The tracheomalacia model was successfully established in 12 rabbits, and PDO stents were placed in eight of those rabbits.

Results

The PDO stent was successfully positioned in the trachea of the normal rabbits using an endoscopic approach, and its degradation was obs

SUBMITTER: Choi JS 

PROVIDER: S-EPMC8373836 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature