A non-invasive olfactory bulb measure dissociates Parkinson's patients from healthy controls and discloses disease duration.

ABSTRACT: Olfactory dysfunction is a prevalent non-motor symptom of Parkinson's disease (PD). This dysfunction is a result of neurodegeneration within the olfactory bulb (OB), the first processing area of the central olfactory system, and commonly precedes the characteristic motor symptoms in PD by several years. Functional measurements of the OB could therefore potentially be used as an early biomarker for PD. Here, we used a non-invasive method, so-called electrobulbogram (EBG), to measure OB function in PD and age-matched healthy controls to assess whether EBG measures can dissociate PDs from controls. We estimated the spectrogram of the EBG signal during exposure to odor in PD (n = 20) and age-matched controls (n = 18) as well as identified differentiating patterns of odor-related synchronizatio

SUBMITTER: Iravani B 

PROVIDER: S-EPMC8373926 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature