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Etiological and epidemiological features of acute respiratory infections in China.

ABSTRACT: Nationwide prospective surveillance of all-age patients with acute respiratory infections was conducted in China between 2009‒2019. Here we report the etiological and epidemiological features of the 231,107 eligible patients enrolled in this analysis. Children <5 years old and school-age children have the highest viral positivity rate (46.9%) and bacterial positivity rate (30.9%). Influenza virus, respiratory syncytial virus and human rhinovirus are the three leading viral pathogens with proportions of 28.5%, 16.8% and 16.7%, and Streptococcus pneumoniae, Mycoplasma pneumoniae and Klebsiella pneumoniae are the three leading bacterial pathogens (29.9%, 18.6% and 15.8%). Negative interactions between viruses and positive interactions between viral and bacterial pathogens are common. A Join-Point analysis reveals the age-specific positivity rate and how this varied for individual pathogens. These data indicate that differential priorities for diagnosis, prevention and control should be highlighted in terms of acute respiratory tract infection patients' demography, geographic locations and season of illness in China.

SUBMITTER: Li ZJ

PROVIDER: S-EPMC8373954 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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Etiological and epidemiological features of acute respiratory infections in China.

Li Zhong-Jie ZJ Zhang Hai-Yang HY Ren Li-Li LL Lu Qing-Bin QB Ren Xiang X Zhang Cui-Hong CH Wang Yi-Fei YF Lin Sheng-Hong SH Zhang Xiao-Ai XA Li Jun J Zhao Shi-Wen SW Yi Zhi-Gang ZG Chen Xiao X Yang Zuo-Sen ZS Meng Lei L Wang Xin-Hua XH Liu Ying-Le YL Wang Xin X Cui Ai-Li AL Lai Sheng-Jie SJ Jiang Tao T Yuan Yang Y Shi Lu-Sha LS Liu Meng-Yang MY Zhu Yu-Liang YL Zhang An-Ran AR Zhang Zhi-Jie ZJ Yang Yang Y Ward Michael P MP Feng Lu-Zhao LZ Jing Huai-Qi HQ Huang Liu-Yu LY Xu Wen-Bo WB Chen Yu Y Wu Jian-Guo JG Yuan Zheng-Hong ZH Li Meng-Feng MF Wang Yu Y Wang Li-Ping LP Fang Li-Qun LQ Liu Wei W Hay Simon I SI Gao George F GF Yang Wei-Zhong WZ

Nature communications 20210818 1

Nationwide prospective surveillance of all-age patients with acute respiratory infections was conducted in China between 2009‒2019. Here we report the etiological and epidemiological features of the 231,107 eligible patients enrolled in this analysis. Children <5 years old and school-age children have the highest viral positivity rate (46.9%) and bacterial positivity rate (30.9%). Influenza virus, respiratory syncytial virus and human rhinovirus are the three leading viral pathogens with proport ...[more]

PMID: 34408158

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Dataset Information

Etiological and epidemiological features of acute respiratory infections in China.

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Etiological and epidemiological features of acute respiratory infections in China.

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