Association of metformin and development of dry age-related macular degeneration in a U.S. insurance claims database.

ABSTRACT:

Purpose

To assess whether metformin is associated with dry age-related macular degeneration (dAMD) development.

Methods

In this retrospective cohort study, patients enrolled in a nationwide U.S. medical insurance claims database from 2002 to 2016 were included if they had diabetes mellitus, were ⩾55 years old, and were enrolled for ⩾2 years without a prior AMD diagnosis. The primary exposure was metformin use analyzed as either active or prior use or cumulative metformin dosage over the study period. A time updating Cox proportional hazard regression was used to estimate the hazard ratio of dAMD incidence with metformin exposure.

Results

Among 1,007,226 diabetic enrollees, 53.3% were female and 66.4% were white with a mean hemoglobin A1c of 6.8%. Of eligible enrollees

SUBMITTER: Eton EA 

PROVIDER: S-EPMC8374004 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature