Saccharomyces cerevisiae as host for the recombinant production of polyketides and nonribosomal peptides.

ABSTRACT: As a robust, fast growing and genetically tractable organism, the budding yeast Saccharomyces cerevisiae is one of the most widely used hosts in biotechnology. Its applications range from the manufacturing of vaccines and hormones to bulk chemicals and biofuels. In recent years, major efforts have been undertaken to expand this portfolio to include structurally complex natural products, such as polyketides and nonribosomally synthesized peptides. These compounds often have useful pharmacological properties, which make them valuable drugs for the treatment of infectious diseases, cancer, or autoimmune disorders. In nature, polyketides and nonribosomal peptides are generated by consecutive condensation reactions of short chain acyl-CoAs or amino acids, respectively, with the substrates and r

SUBMITTER: Tippelt A 

PROVIDER: S-EPMC8374128 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature