The newly synthesized thiazole derivatives as potential antifungal compounds against Candida albicans.

ABSTRACT: Recently, the occurrence of candidiasis has increased dramatically, especially in immunocompromised patients. Additionally, their treatment is often ineffective due to the resistance of yeasts to antimycotics. Therefore, there is a need to search for new antifungals. A series of nine newly synthesized thiazole derivatives containing the cyclopropane system, showing promising activity against Candida spp., has been further investigated. We decided to verify their antifungal activity towards clinical Candida albicans isolated from the oral cavity of patients with hematological malignancies and investigate the mode of action on fungal cell, the effect of combination with the selected antimycotics, toxicity to erythrocytes, and lipophilicity. These studies were performed by the broth microdilu

SUBMITTER: Biernasiuk A 

PROVIDER: S-EPMC8374424 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature