¹¹C-PK11195 plasma metabolization has the same rate in multiple sclerosis patients and healthy controls: a cross-sectional study.

ABSTRACT: ¹¹C-PK11195 is a positron emitter tracer used for Positron Emission Tomography (PET) imaging of innate immune cell activation in studies of neuroinflammatory diseases. For the image quantitative analysis, it is necessary to quantify the intact fraction of this tracer in the arterial plasma during imaging acquisition (plasma intact fraction). Due to the complexity and costs involved in this analysis it is important to evaluate the real necessity of individual analysis in each ¹¹C-PK11195 PET imaging acquisition. The purpose of this study is to compare ¹¹C-PK11195 plasma metabolization rate between healthy controls and multiple sclerosis (MS) patients and evaluate the interference of sex, age, treatment, and disease phenotype in the tracer intact fraction mea

SUBMITTER: de Souza AM 

PROVIDER: S-EPMC8374550 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature